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KMID : 0605720100160010072
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Journal of the Korean Society of Biological Therapies in Psychiatry
2010 Volume.16 No. 1 p.72 ~ p.79
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Changes of Quality of Life in the Treatment of Acute Onset Schizophrenic Patients with Amisulpride
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So Kyo-Ok
Lee Jong-Hun
Choi Tae-Young
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Abstract
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Objectives: The purpose of this study is to assess the changes of quality of life in the treatment of acute onset schizophrenic patients with amisulpride. Also, we investigated how the subjective quality of life is related with patients’ depression, attitude to medication, satisfaction to medication, psychopathology, symptom severity, symptom improvement and functioning of schizophrenia.
Methods: 54 schizophrenic patients in 6 hospitals were administered amisulpride. Psychiatric status was evaluated by Korean version of 4th Revision of Schizophrenia Quality of Life Scale(SQLS-R4K), Korean version of Calgary Depression Scale for Schizophrenia(K-CDSS), Korean version of Drug Attitude Inventory(KDAI-10), Drug Satisfaction Questionaire(DSQ), Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression scale(CGI) and Global Assessment of Functioning Scale(GAF Scale) at baseline, day1, week2, week4 and week6.
Results: Subjective quality of life and depressive symptom were improved significantly after administering amisulpride. Subjective quality of life was related significantly with total score, negative, positive symptom and general psychopathology score in PANSS. Subjective quality of life correlated significantly with drug satisfaction, but not drug attitude, depressive symptoms, CGI-S, CGI-I and GAF score.
Conclusions: This study suggests that the subjective quality of life of schizophrenic patients, who had treated with amisulpride, is influenced significantly. Active management for positive, negative symptoms and drug side effect is recommended to improve patients’ quality of life.
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KEYWORD
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Schizophrenia, Atypical antipsychotics, Amisulpride
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